EnergyBalance AHC Complete® natural defences, with alfa and beta glucans, 90 Vege Caps, BBE* 02/2025

What is Hexose Correlated Compound?
EnergyBalance AHC Complete® (the abbreviation for Active Hexose Correlated Compound) is a food supplement made out of mycelium of the Shiitake mushroom (Lentinus edodes). Shiitake is a very important edible mushroom in Japan and China, used in gastronomy as well as in traditional medicine due to its effective medicinal power. Unlike a simple vitamin or mineral preparation, EnergyBalance AHC Complete® is a very complex mixture, made of many different natural substances. In addition to amino acids, fatty acids, vitamins and minerals, it also contains alpha-glucans, the most important component of EnergyBalance AHC Complete®.

20% of Ative Hexose Compound dry weight it is actually made of short-chain acetylated alpha-glucans. These special glucans are able to pass through the intestinal mucosa much more easily than long-chain glucans. Moreover they are not found in the body of the shiitake mushroom, but only in the filaments of the mycelium: they must therefore not be confused with the simple dried mushroom. These types of glucans - modified in the production process - are contained exclusively in the Active Hexose Correlated Compound.

In traditional naturopathy, glucan-rich mushroom and cereal extracts have played an important role in many cultures for centuries. In evidence-based medicine, the many health-promoting effects of glucans from plants and fungi have been known since the late 20th century. Dietary fiber has proven to be fundamental in nutrition; and dietary fiber such as glucans regulate blood sugar and fat levels and are indispensable for intestinal flora. Today the interest of research is going further: the different types of glucans (alpha and beta) are in fact taken into consideration by some studies for their potential effectiveness on the immune system (see bibliography of the studies at the bottom of the page).

What effects do the active ingredients in Energy Balance AHC Complete® have?
Scientific literature tells us that alpha-glucans behave as if they were immunostimulants and immunomodulators. This means that the right combination of active ingredients, such as these, may be able to support the immune system. Normally the so-called immune modulators on the one hand can activate and improve the body's defences, while on the other hand they can regulate and normalise an overactive immune system.

What distinguishes EnergyBalance AHCComplete® from AHCC®?
In EnergyBalance AHCComplete®, alpha glucans (300mg daily portion) have been integrated with other natural "immune-active" ingredients to obtain a synergistic effect of the various components, by implementing the natural physiological defence. In addition to alpha-glucans, EnergyBalance AHCComplete® contains:

Beta-1,3-glucans
The several stimulating properties of Beta-glucans, obtained from yeasts, have been demonstrated in over 80 clinical studies. Glucans have an impact on many aspects of the body: they activate both the cells of the non-specific defence and those of the specific defence - in other words, they strengthen the entire defensive system.

Ginger extract (gingerol and 6-shogaol)
Ginger - one of the oldest medicinal plant in the world - has renowned antioxidant, antimicrobial, anti-inflammatory properties.  Many studies suggest that ginger aGinger - one of the oldest medicinal plant in the world - has renowned antioxidant, antimicrobial, anti-inflammatory properties.  Many studies suggest that ginger and its extracts (gingerol and 6-shogaol) are very important as preventive food supplement.nd its extracts (gingerol and 6-shogaol) are very important as preventive food supplement.

Oleuropein - natural defence system
Olive trees are highly resistant to fungal attacks and diseases. Some olive trees are long living. Such characteristic seems to be due to its natural defence system which protects the tree from being attacked. Olive leaves, unripe olives (and to a lesser extent ripe olives and unrefined olive oil) are rich of polyphenols, the effects of which are well known today. Numerous highly protective effects have been demonstrated for the most important of these substances (oleuropein). This is why there are olive trees capable of living up to 1000 years.

Natural vitamin D, from inactive yeast
Numerous experimental studies have led to the fact that vitamin D is no longer only considered for its classic role in calcium metabolism, but it also has an important function as an immunomodulator: almost every types of immune cells have receptors for vitamin D on their surfaces. This is why EnergyBalance AHC Complete® also contains natural vitamin D.

Selenium (from inactive yeast)
Selenium is probably one of the most underrated micronutrients. Such trace element is though a central component of selenoproteins, which play on important role in the immune related processes. The integration with selenium stimulates the body's natural defences. To be exact it is "selenium yeast", a beer yeast grown on a nutrient of selenium, which is rich in selenomethionine and selenocysteine amino acids.

Recommended daily intake
3x1 time before meals

Ingedients
Saccharomyces cerevisiae (beta glucans), mycelia extract from Lentinula edodes as alpha glucans (Active Hexose Correlated Compound), olive leaf extract (oleuropein), Zingiber medicinal plant (ginger extract: gingerol, 6-shogaol), selenium (inactive yeast), vitamin D (inactive yeast); cellulose (VegeCaps).

Content
66g = 90 VegeCaps of 621mg each

Studies:
(1) Active Hexose Correlated Compound Exerts Therapeutic Effects in Lymphocyte Driven Colitis. Cristina Mascaraque, María Dolores Suárez, Antonio Zarzuelo, Fermín Sánchez de Medina, Olga Martínez-Augustin. Molecular Nutrition and Food Research 58 (12), 2379-82 (2014)
(2) A*ctive Hexose-Correlated Compound and Bifidobacterium Longum BB536 Exert Symbiotic Effects in Experimental Colitis. Borja Ocón, Andrea Anzola, Mercedes Ortega-González, Antonio Zarzuelo, María D Suárez, Fermín Sánchez de Medina, Olga Martínez-Augustin. European Journal of Nutrition 52 (2), 457-66 (2013)
(3) Amelioration by A*ctive Hexose Correlated Compound of Endocrine Disturbances Induced by Oxidative Stress in the Rat. She-Fang Ye, K Wakame, K Ichimura, S Matsuzaki. Endocrine Regulation 38 (1), 7-13 (2004)
(4) Supplementation With A*ctive Hexose Correlated Compound Increases Survival Following Infectious Challenge in Mice. Barry W. Ritz. Nutrition Reviews 66 (9), 526-31 (2008)
(5) A*ctive Hexose Correlated Compound Activates Immune Function to Decrease Bacterial Load in a Murine Model of Intramuscular Infection. Hernan Aviles, Phyllis O'Donnell, Julia Orshal, Hajime Fujii, Buxiang Sun, Gerald Sonnenfeld. American Journal of Surgery 195 (4), 537-45 (2008)
(6) A*ctive Hexose Correlated Compound promotes T helper (Th) 17 and 1 cell responses via inducing IL-1β production from monocytes in humans. Won-Woo Lee, Naeun Lee, Hajime Fujii, and Insoo Kang. Cellular immunology 275 (1-2), 19-23 (2012)
(7) Effects of A*ctive Hexose Correlated Compound on Frequency of CD4+ and CD8+ T Cells Producing Interferon-γ and/or Tumor Necrosis Factor-α in Healthy Adults. Zhinan Yin, Hajime Fujii, Thomas Walshe. Human Immunology 71 (12), 1187-90 (2010)
(8) Short-term Supplementation With A*ctive Hexose Correlated Compound Improves the Antibody Response to Influenza B Vaccine. Brooke E Roman, Eleni Beli, David M Duriancik, Elizabeth M Gardner. Nutrition Research 33 (1), 12-7 (2013)
(9) Immunological Effect of A*ctive Hexose Correlated Compound (AHCC) in Healthy Volunteers: A Double-Blind, Placebo-Controlled Trial. Naoyoshi Terakawa, Yoichi Matsui, Sohei Satoi, Hiroaki Yanagimoto, Kanji Takahashi, Tomohisa Yamamoto, Jun Yamao, Soichiro Takai, A-Hon Kwon, Yasuo Kamiyama. Nutrition and Cancer 60 (5), 643-51 (2008)
(10) A*ctive Hexose Correlated Compound Potentiates the Antitumor Effects of Low-Dose 5-fluorouracil Through Modulation of Immune Function in Hepatoma 22 Tumor-Bearing Mice. Zhiyun Cao, Xuzheng Chen, Lan Lan, Zhideng Zhang, Jian Du, Lianming Liao. Nutrition Research and Practice 9 (2), 129-36 (2015)
(11) Combination Therapy of A*ctive Hexose Correlated Compound Plus UFT Significantly Reduces the Metastasis of Rat Mammary Adenocarcinoma. K Matsushita, Y Kuramitsu, Y Ohiro, M Obara, M Kobayashi, Y Q Li, M Hosokawa. Anticancer Drugs 9 (4), 343-50 (1998)
(12) Alleviating Effect of A*ctive Hexose Correlated Compound (AHCC) for Anticancer Drug-Induced Side Effects in Non-Tumor-Bearing Mice.Kota Shigama, Akihiro Nakaya, Koji Wakame, Hiroshi Nishioka, Hajime Fujii. Journa of Experimental Therapeutics and Oncology 8 (1), 43-51 (2009)
(13) Alleviating Effect of A*ctive Hexose Correlated Compound (AHCC) on Chemotherapy-Related Adverse Events in Patients With Unresectable Pancreatic Ductal Adenocarcinoma. Hiroaki Yanagimoto, Sohei Satoi, Tomohisa Yamamoto, Satoshi Hirooka, So Yamaki, Masaya Kotsuka, Hironori Ryota, Taku Michiura, Kentaro Inoue, Yoichi Matsui, Koji Tsuta, Masanori Kon. Nutrition and Cancer 68 (2), 234-40 (2016)
(14) Effect of A*ctive Hexose-Correlated Compound in Women Receiving Adjuvant Chemotherapy for Breast Cancer: A Retrospective Study. Sho Hangai, Satoru Iwase, Takashi Kawaguchi, Yasunori Kogure, Tempei Miyaji, Tadaharu Matsunaga, Yoshinori Nagumo, Takuhiro Yamaguchi. Journal of Alternative and Complementray Medicine 19 (11), 905-10 (2013)
(15) Reduction of Adverse Effects by a Mushroom Product, A*ctive Hexose Correlated Compound (AHCC) in Patients With Advanced Cancer During Chemotherapy--The Significance of the Levels of HHV-6 DNA in Saliva as a Surrogate Biomarker During Chemotherapy. Toshinori Ito, Hayato Urushima, Miki Sakaue, Sayoko Yukawa, Hatsumi Honda, Kei Hirai, Takumi Igura, Noriyuki Hayashi, Kazuhisa Maeda, Toru Kitagawa, Kazuhiro Kondo. Nutrition and Cancer 66 (3), 377-82 (2014)
(16) The Influence of A*ctive Hexose Correlated Compound (AHCC) on Cisplatin-Evoked Chemotherapeutic and Side Effects in Tumor-Bearing Mice. Aya Hirose, Eri Sato, Hajime Fujii, Buxiang Sun, Hiroshi Nishioka, Okezie I Aruoma. Toxicology and Applied Pharmacology 222 (2), 152-8 (2007)
(17) Improved Prognosis of Postoperative Hepatocellular Carcinoma Patients When Treated With Functional Foods: A Prospective Cohort Study. Yoichi Matsui, Junya Uhara, Sohei Satoi, Masaki Kaibori, Hitoshi Yamada, Hiroaki Kitade, Atsusi Imamura, Soichiro Takai, Yusai Kawaguchi, A-Hon Kwon, Yasuo Kamiyama. Journal of Hepatology 37 (1), 78-86 (2002)
(18) Disruption of Endothelial Adherens Junction by Invasive Breast Cancer Cells Is Mediated by Reactive Oxygen Species and Is Attenuated by AHCC. Mehran Haidari, Wei Zhang, Koji Wakame Life Sciences 93 (25-26), 994-1003 (2013)
(19) Active Hexose-Correlated Compound Down-Regulates Sex-Determining Region Y-box 2 of Pancreatic Cancer Cells. Junya Nawata, Yasuhiro Kuramitsu, Yufeng Wang, Takao Kitagawa, Kazuhiro Tokuda, Byron Baron, Junko Akada, Shigeyuki Suenaga, Seiji Kaino, Shin-Ichiro Maehara, Yoshihiko Maehara, Isao Sakaida, Kazuyuki Nakamura. Anticancer Research 34 (9), 4807-11 (2014)
(20) MicroRNA Signature in the Chemoprevention of Functionally-Enriched Stem and Progenitor Pools (FESPP) by A*ctive Hexose Correlated Compound (AHCC). Émilie A Graham, Jean-François Mallet, Majed Jambi, Hiroshi Nishioka, Kohei Homma, Chantal Matar. Cancer Biology and Therapy 18 (10), 765-774 (2017)
(21) Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation. Jin Young Choi, Seul Lee, Sun-Mi Yun, Dong Hoon Suh, Kidong Kim, Jae Hong No, Eun-Hwan Jeong, Yong Beom Kim. Nutrition and Cancer 70 (1), 109-115 (2018)
(22) Active Hexose-Correlated Compound Enhances Extrinsic-Pathway-Mediated Apoptosis of Acute Myeloid Leukemic Cells. Kavin Fatehchand, Ramasamy Santhanam, Brenda Shen, Ericka L Erickson, Shalini Gautam, Saranya Elavazhagan, Xiaokui Mo, Tesfaye Belay, Susheela Tridandapani, Jonathan P Butchar. PloS One 12 (7), e0181729 (2017)
(23) Dramatic Prostate-Specific Antigen Response With Activated Hemicellulose Compound in Metastatic Castration-Resistant Prostate Cancer. Jeffrey Turner, Uzair Chaudhary. Anticancer Drugs 20 (3), 215-6 (2009)
(24) Dietary Administration of Mushroom Mycelium Extracts in Patients With Early Stage Prostate Cancers Managed Expectantly: A Phase II Study. Yoshiteru Sumiyoshi, Katsuyoshi Hashine, Yoshiyuki Kakehi, Koji Yoshimura, Takehumi Satou, Hidetoshi Kuruma, Syunichi Namiki, Nobuo Shinohara. Japanese Journal of Clinical Oncology 40 (10), 967-72 (2010)
(25) Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials. by Vaclav Vetvicka, Luca Vannucci, Petr Sima and Josef Richter. Molecules 24(7), 1251 (2019)
(26) Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe). Qian-Qian Mao, Xiao-Yu Xu, Shi-Yu Cao, Ren-You Gan, Harold Corke, Trust Beta, Hua-Bin Li. Foods 8 (6) (2019)
(27) Effects of the Olive-Derived Polyphenol Oleuropein on Human Health. Barbara Barbaro, Gabriele Toietta, Roberta Maggio, Mario Arciello, Mirko Tarocchi, Andrea Galli, Clara Balsano. International Journal of Molecular Sciences 15 (10), 18508-24 (2014)
(28) Oleuropein and Cancer Chemoprevention: The Link Is Hot. Ammad Ahmad Farooqi, Sundas Fayyaz, Ana Sanches Silva, Antoni Sureda, Seyed Fazel Nabavi, Andrei Mocan, Seyed Mohammad Nabavi, Anupam Bishayee. Molecules 22 (5) (2017)
(29) Vitamin D: Nutrient, Hormone, and Immunomodulator. Francesca Sassi, Cristina Tamone, Patrizia D'Amelio. Nutrients 10 (11) (2018)
(30) Selenium, Selenoproteins, and Immunity. Joseph C Avery, Peter R Hoffmann. Nutrients 10 (9) (2018)